Management of cutaneous side effects of cetuximab therapy with vitamin K1 crème

Management of cutaneous side effects of cetuximab therapy with vitamin K1 crème

Background. Cetuximab is a chimeric human-murine monoclonal antibody against the epidermal growth factor receptor (EGFR). It has shown activities against multiple malignancies in clinical trials. EGFR-inhibitors often cause skin toxicity, most frequently acneiform eruption. Xerosis, eczema, fissures, teleangiectasias, nail changes and paronychia can be seen in some cases, rarely hyperpigmentati...

Management of cetuximab-induced skin toxicity with the prophylactic use of topical vitamin K1 cream

Cetuximab is an immunoglobulin G1 monoclonal antibody that binds to the extracellular domain of the epidermal growth factor receptor (EGFR) blocking ligand-induced auto-phosphorylation and subsequent receptor mediated signalling.1,2 Cetuximab in combination with chemotherapy is effective in the treatment of EGFR-expressing tumors including metastatic colorectal cancer (mCRC).2,3 EGFR is strongl...

Management of Cutaneous and Extracutaneous Side Effects of Smoothened Inhibitor Therapy for Advanced Basal Cell Carcinoma.

Smoothened inhibitors represent the first class of targeted drugs approved for use in advanced and metastatic basal cell carcinoma. For many patients with limited treatment options, this drug class has led to significant clinical improvements, but is not without side effects. In this review, we outline the basic mechanism of smoothened inhibitors and the most commonly observed cutaneous and ext...

CUTANEOUS SIDE EFFECTS OF TARGETED THERAPY FOR COlORECTAl CARCINOMA

Cutaneous side-effects of EGFR inhibitors and their management.

Epidermal growth factor receptor (EGFR) inhibitors are an increasingly important treatment option for metastasized cancer in patients. In addition to the pivotal role of EGFR in the development and progression of malignant tumors, EGFR is also important for proliferation and differentiation of the human epidermis and hair follicles. As a consequence, cutaneous side-effects are frequently observ...